Advantages of NK Cells

NKCL Classic
1 min readApr 18, 2024

Due to their natural ability to recognize and lyse tumor cells using a variety of recognition receptors, NK cells have been examined clinically in several immunotherapeutic strategies for cancer. As NK cells are found primarily in the blood and rarely infiltrate solid tissue tumors, NK immunotherapies have been most successful in hematopoietic malignancies, although they have also been examined in many non-hematopoietic and metastatic cancers. NK cells are antigen non-specific and do not require the expression of a specific antigen expressed on a given HLA allotype. Rather, NK cells recognize a broad panel of several dozen ligands which can each induce a cytolytic response. NK cells can be easily isolated and expanded ex vivo which allows for their use in adoptive or autologous cell therapies. Also, NK cells have a lifespan much shorter than that of T cells.

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NKCL Classic

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